July
29
2022
11:00 AM

Contact

Location

Virtual
Friday, July 29, 2022 11:00AM

Date: Friday, July 29, 2022

Time: 11:00 a.m.

Virtual: View meeting instructions below

Speaker: Amy Kuceyeski 

Speaker’s Title: Associate Professor of Mathematics in the Radiology Department at Weill Cornell Medicine and an Adjunct Associate Professor in the Computational Biology Department at Cornell University

Seminar Title: Toward Causality in the Bain: From Lesions to Psychedelics

The recent explosion of neuroimaging studies in large-scale populations of humans has begin to reveal complex mappings between brain and behavior. Cross-sectional studies do not allow, however, for exploring causality in the brain. Lesion studies have historically allowed direct linking between an area of damage and a specific behavioral change, and more recent virtual lesion (TMS), ECoG and pharmacological experiments have allowed exploration of the effect of manipulating brain function on behavior. These type of studies take steps in the direction of understanding causality in brain-behavior relationships. In her talk, Amy will discuss recent work in this area and present some of her own work studying the effect of damage on both brain structure/function and behavior, how the brain recovers from damage and how psychedelics may impact whole-brain function.

Biosketch: Amy Kuceyeski is an Associate Professor of Mathematics in the Radiology Department at Weill Cornell Medicine and an Adjunct Associate Professor in the Computational Biology Department at Cornell University. She was awarded her PhD in 2009 from Case Western Reserve University and spent her postdoctoral fellowship and early faculty years at Weill Cornell Medicine. For over a decade, Amy has been interested in understanding how the human brain works in order to better diagnose, prognose and treat neurological disease and injury. Quantitative approaches, including mathematical modeling and machine learning, applied to data from rapidly evolving neuroimaging techniques, have the potential to enable ground-breaking discoveries about how the brain works. Amy has particular interest in lesion-symptom mapping, non-invasive brain stimulation and pharmacological interventions, like psychedelics, that may be used to modulate brain activity and promote recovery from disease or injury.

Recommended Article:

  • Kuceyeski, A., Maruta, J., Relkin, N., Raj, A., 2013. The Network Modification (NeMo) Tool: elucidating the effect of white matter integrity changes on cortical and subcortical structural connectivity. Brain Connect 3, 451-463. Link to Paper
  • Kuceyeski, A. , Jamison, K.W., Owen, J.P., Raj, A., Mukherjee, P., 2019. Longitudinal increases in structural connectome segregation and functional connectome integration are associated with better recovery after mild TBI.Hum Brain Mapp 40, 4441-4456. Link to Paper
  • Tozlu, C., Jamison, K., Gu, Z., Gauthier, S.A., Kuceyeski, A., 2021. Estimated connectivity networks outperform observed connectivity networks when classifying people with multiple sclerosis into disability groups. Neuroimage Clin 32, 102827. Link to Paper
  • Olafson, E.R., Jamison, K.W., Sweeney, E.M., Liu, H., Wang, D., Bruss, J.E., Boes, A.D., Kuceyeski, A., 2021. Functional connectome reorganization relates to post-stroke motor recovery and structural and functional disconnection. Neuroimage 245, 118642. Link to Paper
  • Singleton P, Luppi A, Carhart-Harris RL, Cruzat J, Roseman L, Deco G, Kringelbach M, Stamatakis EA, Kuceyeski A. Psychedelics flatten the brain’s energy landscape: evidence from receptor-informed network control theory. Nature Communications (in press). 
  • Olafson E, Russello G, Jamison K, Liu H, Wang D, Bruss J, Boes A, Kuceyeski A. Increased prevalence of a frontoparietal brain state is associated with better motor recovery after stroke affecting dominant-hand cortico-spinal tract. Communications Biology (in press). 

Meeting Instructions: