ECE Course Outline

ECE4784

Engineering Electrophysiology (3-0-3)

Prerequisites
EC E 3030 [min C] or ECE 3040 [min C] or BMED 3510
Corequisites
None
Catalog Description
Basic concepts of electrophysiology from an engineering perspective. Functionality of relevant organs and systems; instrumentation tools which monitor electrophysiological function. Crosslisted with BMED 4784.
Textbook(s)
Barr & Plonsey, Bioelectricity: A Quantitative Approach (3rd edition), Springer, 2000. ISBN 9780387488646 (required)

Topical Outline
Membrane Biophysics
* Diffusion across cell membranes
* Nernst potentials, Diffusion potentials
* Goldman equation

Action Potentials
* Membrane behavior, Origin of action potentials
* Hodgkin-Huxley equations, Modeling
* Propagation of action potentials
* Subthreshold stimuli

Extracellular Fields
* Monopole and dipole models

Cellular Analysis Technologies
* Coulter counter
* Impedance spectroscopy, Fluorescence spectroscopy
* Molecular tagging
* Electrodes

Electrophysiology of the Heart
* Anatomy/physiology of the heart, Heart vector
* Electrode configurations, Recording
* Body surface potentials, Interface electronics

Neuromuscular Junction
* Transmitters
* Poisson statistics
* Post-junctional responses

Skeletal Muscle
* Anatomy/physiology of muscle
* Myofibrils and filaments
* Excitation contraction

Functional Neuromuscular Stimulation
* Electrodes
* Nerve excitation

Interface Circuitry and Systems
* Neurophysiological analysis systems
* Skeletal muscle interfaces
* Blood Analysis

Advanced Electrophysiological Analysis Systems
* Micro systems
* Metabolite monitoring
* Prosthetic devices / bionics