Micro-Physiological Systems Seminar Series

Event Details

Wednesday, November 20, 2019

1:00pm - 2:00pm

Location: 
Whitaker Building (BME), Room 1103

For More Information

Contact:

Shuichi Takayama, faculty host

Event Details

"Bioengineered Human iPSC Tissue Model for Gaining Mechanistic and Therapeutic Insights into CPVT"

Sung Jin Park, Ph.D.
Assistant Professor
Coulter Department of Biomedical Engineering
Georgia Tech/Emory University

The cellular phenotypes caused by inherited arrhythmia mutations have been studied using human induced pluripotent stem cell derived cardiomyocytes (hiPSC-CMs). However, arrhythmias are the emergent properties of cells assembled into tissues, and the impact of these mutations on tissue-level properties of human myocardium has not been reported. In this talk, I will present an in vitro hiPSC-CM-based platform to study the tissue-level properties of engineered human myocardium. I will illustrate how this hiPSC-CM-based platform can be used to investigate pathogenic mechanisms in the deadly, exercise-triggered inherited arrhythmia catecholaminergic polymorphic ventricular tachycardia (CPVT). In addition, I will show how we combined this novel platform with genome editing and identified new therapeutic target for CPVT.

Last revised November 12, 2019